Supercritical CO2 Assisted Electrospray to Produce Poly(lactic-co-glycolic Acid) Nanoparticles
نویسندگان
چکیده
This work proposes an improvement of the traditional electrospraying process, in which supercritical carbon dioxide (SC-CO2) is used to produce poly(lactic-co-glycolic acid) (PLGA) nanoparticles. The experiments were performed at different PLGA concentrations (1, 3 and 5% w/w), applied voltages (10 30 kV) operating pressures (80, 120 140 bar). It was found that working bar kV, spherical nanoparticles, with mean diameters 101 ± 13 nm 151 45 nm, obtained, when solutions 1% w/w 3% electrosprayed, respectively. Increasing concentration up w/w, a mixture fibers particles observed, indicating transition electrospinning regime.
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ژورنال
عنوان ژورنال: ChemEngineering
سال: 2022
ISSN: ['2305-7084']
DOI: https://doi.org/10.3390/chemengineering6050066